Transcription factors with Perturb-seq knockdown data for ENSG00000291259. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291259 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291259, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:28,095,795–28,097,469 | 493.3 kb | Distal (>10kb) Multiome HiCAR | 345 | |
| chr15:28,098,647–28,099,761 | 490.2 kb | Distal (>10kb) Multiome HiCAR | 378 | |
| chr15:28,832,103–28,832,591 | 242.8 kb | Distal (>10kb) Multiome | 201 | |
| chr15:28,885,430–28,886,683 | 296.5 kb | Distal (>10kb) Multiome | 340 |
Genomic view of the ENSG00000291259 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.