Transcription factors with Perturb-seq knockdown data for ENSG00000291176. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291176 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291176, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:95,388,847–95,389,649 | 621.2 kb | Distal (>10kb) Multiome HiCAR | 269 | |
| chr2:95,401,933–95,403,542 | 607.9 kb | Distal (>10kb) Multiome HiCAR | 885 | |
| chr2:95,713,301–95,714,629 | 296.6 kb | Distal (>10kb) Multiome | 154 | |
| chr2:96,116,133–96,117,547 | 106.3 kb | Distal (>10kb) Multiome HiCAR | 470 | |
| chr2:96,138,522–96,139,006 | 128.2 kb | Distal (>10kb) Multiome | 255 | |
| chr2:96,144,225–96,145,701 | 134.8 kb | Distal (>10kb) Multiome | 423 | |
| chr2:96,148,417–96,148,969 | 138.2 kb | Distal (>10kb) Multiome | 318 | |
| chr2:96,207,850–96,209,429 | 198.4 kb | Distal (>10kb) Multiome | 1022 | |
| chr2:96,265,014–96,266,655 | 255.6 kb | Distal (>10kb) Multiome | 992 | |
| chr2:96,305,302–96,305,947 | 295.1 kb | Distal (>10kb) Multiome | 918 |
Genomic view of the ENSG00000291176 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.