Transcription factors with Perturb-seq knockdown data for ENSG00000291175. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291175 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291175, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:45,316,202–45,317,910 | 267.4 kb | Distal (>10kb) Multiome | 857 | |
| chr17:45,334,174–45,334,847 | 250.2 kb | Distal (>10kb) Multiome | 149 | |
| chr17:45,371,481–45,372,140 | 212.7 kb | Distal (>10kb) Multiome | 704 | |
| chr17:45,395,009–45,395,645 | 189.3 kb | Distal (>10kb) Multiome | 482 | |
| chr17:45,404,953–45,406,129 | 179.1 kb | Distal (>10kb) Multiome | 244 | |
| chr17:45,425,403–45,426,061 | 158.8 kb | Distal (>10kb) Multiome | 506 | |
| chr17:45,427,967–45,428,575 | 156.4 kb | Distal (>10kb) Multiome | 454 | |
| chr17:45,429,511–45,430,237 | 154.8 kb | Distal (>10kb) Multiome | 190 | |
| chr17:45,431,253–45,432,633 | 152.9 kb | Distal (>10kb) Multiome | 435 | |
| chr17:45,783,636–45,785,394 | 199.7 kb | Distal (>10kb) Multiome | 464 | |
| chr17:46,192,562–46,194,450 | 609.4 kb | Distal (>10kb) Multiome HiCAR | 1058 | |
| chr17:46,266,246–46,267,478 | 682.3 kb | Distal (>10kb) Multiome HiCAR | 777 |
Genomic view of the ENSG00000291175 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.