Transcription factors with Perturb-seq knockdown data for ENSG00000291168. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291168 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291168, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:92,669,446–92,670,794 | 139.4 kb | Distal (>10kb) Multiome | 870 | |
| chr9:92,745,472–92,746,004 | 63.9 kb | Distal (>10kb) Multiome | 60 | |
| chr9:92,764,048–92,765,970 | 44.5 kb | Distal (>10kb) Multiome | 941 | |
| chr9:92,808,165–92,809,496 | 504 bp | At TSS Multiome | 398 | |
| chr9:92,809,635–92,809,993 | 67 bp | At TSS | 43 | |
| chr9:92,877,587–92,878,337 | 68.5 kb | Distal (>10kb) Multiome | 591 | |
| chr9:93,058,154–93,059,241 | 249.1 kb | Distal (>10kb) Multiome | 417 | |
| chr9:93,094,880–93,097,281 | 286.3 kb | Distal (>10kb) Multiome | 813 |
Genomic view of the ENSG00000291168 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.