TFs regulating ENSG00000291159 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000291159. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291159 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000291159

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291159, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr15:84,570,159–84,571,300	60.5 kb	Distal (>10kb) Multiome	730
chr15:84,587,808–84,588,502	43.3 kb	Distal (>10kb) Multiome	357
chr15:84,600,331–84,601,554	30.5 kb	Distal (>10kb) Multiome	827
chr15:84,603,386–84,604,192	27.7 kb	Distal (>10kb) Multiome HiCAR	119
chr15:84,630,983–84,631,898	104 bp	At TSS Multiome	649
chr15:84,633,275–84,634,337	2.3 kb	Proximal (<10kb) Multiome	621
chr15:84,653,715–84,654,595	22.9 kb	Distal (>10kb) Multiome	788
chr15:84,657,788–84,658,916	26.9 kb	Distal (>10kb) Multiome	591
chr15:84,715,472–84,717,226	84.9 kb	Distal (>10kb) Multiome	972
chr15:84,734,887–84,735,749	103.7 kb	Distal (>10kb) Multiome	614
chr15:84,747,459–84,749,457	117.0 kb	Distal (>10kb) Multiome	852
chr15:84,816,861–84,818,557	186.3 kb	Distal (>10kb) Multiome	375
chr15:84,928,071–84,928,522	296.9 kb	Distal (>10kb) Multiome	445

Genome Browser

Genomic view of the ENSG00000291159 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.