Transcription factors with Perturb-seq knockdown data for ENSG00000291111. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291111 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291111, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:32,837,981–32,838,977 | 278.0 kb | Distal (>10kb) Multiome | 821 | |
| chr6:32,844,222–32,845,071 | 271.9 kb | Distal (>10kb) Multiome | 534 | |
| chr6:32,853,077–32,854,448 | 262.6 kb | Distal (>10kb) Multiome | 841 | |
| chr6:32,893,822–32,895,230 | 222.1 kb | Distal (>10kb) Multiome | 774 | |
| chr6:32,952,883–32,953,496 | 163.4 kb | Distal (>10kb) Multiome | 366 | |
| chr6:32,967,972–32,971,214 | 147.9 kb | Distal (>10kb) Multiome | 1227 | |
| chr6:32,971,467–32,973,408 | 144.6 kb | Distal (>10kb) Multiome | 1115 | |
| chr6:33,009,348–33,009,899 | 107.0 kb | Distal (>10kb) Multiome | 184 | |
| chr6:33,117,206–33,117,451 | 528 bp | At TSS | 87 | |
| chr6:33,123,779–33,124,012 | 7.1 kb | Proximal (<10kb) | 195 | |
| chr6:33,161,505–33,162,100 | 45.1 kb | Distal (>10kb) Multiome | 589 | |
| chr6:33,199,801–33,201,289 | 83.9 kb | Distal (>10kb) Multiome | 1049 | |
| chr6:33,204,263–33,205,422 | 87.9 kb | Distal (>10kb) Multiome | 762 | |
| chr6:33,208,069–33,208,990 | 92.0 kb | Distal (>10kb) Multiome | 858 | |
| chr6:33,248,132–33,249,983 | 132.7 kb | Distal (>10kb) Multiome | 961 | |
| chr6:33,271,370–33,272,508 | 155.3 kb | Distal (>10kb) Multiome | 1058 | |
| chr6:33,276,685–33,277,905 | 160.7 kb | Distal (>10kb) Multiome | 807 | |
| chr6:33,288,941–33,289,881 | 172.7 kb | Distal (>10kb) Multiome | 701 | |
| chr6:33,297,445–33,300,232 | 181.2 kb | Distal (>10kb) Multiome | 1095 | |
| chr6:33,312,436–33,314,207 | 196.2 kb | Distal (>10kb) Multiome | 795 | |
| chr6:33,317,189–33,318,504 | 201.2 kb | Distal (>10kb) Multiome | 649 | |
| chr6:33,322,636–33,323,832 | 206.5 kb | Distal (>10kb) Multiome | 941 | |
| chr6:33,390,888–33,392,247 | 274.9 kb | Distal (>10kb) Multiome | 993 | |
| chr6:33,409,936–33,411,502 | 293.8 kb | Distal (>10kb) Multiome | 977 |
Genomic view of the ENSG00000291111 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.