Transcription factors with Perturb-seq knockdown data for ENSG00000291089. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291089 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291089, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:37,594,052–37,595,363 | 222.7 kb | Distal (>10kb) Multiome | 835 | |
| chr19:37,654,736–37,656,463 | 161.6 kb | Distal (>10kb) Multiome | 1001 | |
| chr19:37,691,873–37,692,535 | 125.1 kb | Distal (>10kb) Multiome | 609 | |
| chr19:37,719,078–37,720,106 | 97.6 kb | Distal (>10kb) Multiome | 698 | |
| chr19:37,779,176–37,780,039 | 37.7 kb | Distal (>10kb) Multiome | 808 | |
| chr19:37,817,184–37,817,724 | at TSS | At TSS | 147 | |
| chr19:37,906,047–37,907,698 | 89.5 kb | Distal (>10kb) Multiome | 915 | |
| chr19:38,004,389–38,004,823 | 187.3 kb | Distal (>10kb) Multiome | 367 | |
| chr19:38,043,611–38,044,643 | 226.5 kb | Distal (>10kb) Multiome | 66 | |
| chr19:38,074,116–38,074,898 | 257.2 kb | Distal (>10kb) Multiome | 299 |
Genomic view of the ENSG00000291089 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.