Transcription factors with Perturb-seq knockdown data for ENSG00000291081. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291081 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291081, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:129,836,580–129,837,599 | 274.5 kb | Distal (>10kb) Multiome | 170 | |
| chr3:129,892,830–129,894,307 | 217.8 kb | Distal (>10kb) Multiome | 732 | |
| chr3:129,942,122–129,942,744 | 169.1 kb | Distal (>10kb) Multiome | 216 | |
| chr3:130,002,691–130,003,348 | 108.3 kb | Distal (>10kb) Multiome | 99 | |
| chr3:130,057,184–130,058,223 | 53.8 kb | Distal (>10kb) Multiome | 206 | |
| chr3:130,059,037–130,059,750 | 52.1 kb | Distal (>10kb) Multiome | 47 | |
| chr3:130,093,831–130,094,918 | 17.2 kb | Distal (>10kb) Multiome | 148 | |
| chr3:130,105,962–130,106,296 | 5.2 kb | Proximal (<10kb) | 36 | |
| chr3:130,110,749–130,113,016 | 272 bp | At TSS Multiome | 377 |
Genomic view of the ENSG00000291081 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.