Transcription factors with Perturb-seq knockdown data for ENSG00000291054. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291054 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291054, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:136,766,914–136,767,996 | 141.9 kb | Distal (>10kb) Multiome | 451 | |
| chrX:136,880,062–136,881,160 | 28.7 kb | Distal (>10kb) Multiome | 642 | |
| chrX:136,909,020–136,910,524 | 804 bp | At TSS Multiome | 608 | |
| chrX:137,052,413–137,053,085 | 143.1 kb | Distal (>10kb) Multiome | 266 |
Genomic view of the ENSG00000291054 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.