Transcription factors with Perturb-seq knockdown data for ENSG00000291015. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000291015 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000291015, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:38,181,365–38,182,291 | 216.9 kb | Distal (>10kb) Multiome | 676 | |
| chr22:38,201,378–38,203,636 | 196.9 kb | Distal (>10kb) Multiome | 848 | |
| chr22:38,214,397–38,215,017 | 184.0 kb | Distal (>10kb) Multiome | 382 | |
| chr22:38,272,379–38,273,237 | 125.9 kb | Distal (>10kb) Multiome | 526 | |
| chr22:38,317,171–38,317,940 | 81.5 kb | Distal (>10kb) Multiome | 524 | |
| chr22:38,319,024–38,319,874 | 79.3 kb | Distal (>10kb) Multiome | 181 | |
| chr22:38,335,940–38,336,726 | 62.6 kb | Distal (>10kb) Multiome | 297 | |
| chr22:38,353,217–38,354,166 | 45.4 kb | Distal (>10kb) Multiome | 404 | |
| chr22:38,397,117–38,397,516 | at TSS | At TSS | 153 | |
| chr22:38,397,757–38,399,352 | 122 bp | At TSS Multiome | 345 | |
| chr22:38,455,555–38,456,345 | 57.2 kb | Distal (>10kb) Multiome | 403 | |
| chr22:38,461,291–38,461,848 | 62.8 kb | Distal (>10kb) Multiome | 595 | |
| chr22:38,505,466–38,506,961 | 107.6 kb | Distal (>10kb) Multiome | 889 | |
| chr22:38,569,664–38,571,256 | 171.5 kb | Distal (>10kb) Multiome | 559 | |
| chr22:38,655,982–38,657,104 | 257.6 kb | Distal (>10kb) Multiome | 698 | |
| chr22:38,681,730–38,682,262 | 283.1 kb | Distal (>10kb) Multiome | 947 |
Genomic view of the ENSG00000291015 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.