Transcription factors with Perturb-seq knockdown data for ENSG00000290989. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290989 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290989, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:223,711,902–223,713,324 | 280.2 kb | Distal (>10kb) Multiome HiCAR | 708 | |
| chr1:223,748,526–223,749,571 | 243.8 kb | Distal (>10kb) Multiome | 391 | |
| chr1:223,845,336–223,846,577 | 146.7 kb | Distal (>10kb) Multiome | 1001 | |
| chr1:223,870,523–223,871,422 | 121.9 kb | Distal (>10kb) Multiome | 131 | |
| chr1:223,992,339–223,993,214 | 70 bp | At TSS Multiome | 350 | |
| chr1:224,113,911–224,114,795 | 121.4 kb | Distal (>10kb) Multiome | 853 | |
| chr1:224,182,841–224,184,249 | 190.5 kb | Distal (>10kb) Multiome | 901 | |
| chr1:224,329,851–224,330,705 | 337.6 kb | Distal (>10kb) Multiome HiCAR | 865 |
Genomic view of the ENSG00000290989 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.