Transcription factors with Perturb-seq knockdown data for ENSG00000290960. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290960 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290960, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:3,091,645–3,092,317 | 289.0 kb | Distal (>10kb) Multiome | 449 | |
| chr11:3,148,512–3,149,454 | 231.9 kb | Distal (>10kb) Multiome | 152 | |
| chr11:3,160,043–3,161,026 | 220.4 kb | Distal (>10kb) Multiome | 283 | |
| chr11:3,164,925–3,165,485 | 215.7 kb | Distal (>10kb) Multiome | 326 | |
| chr11:3,378,728–3,379,430 | 1.7 kb | Proximal (<10kb) Multiome | 821 | |
| chr11:3,380,404–3,381,449 | 63 bp | At TSS Multiome | 195 | |
| chr11:3,421,770–3,423,686 | 42.0 kb | Distal (>10kb) Multiome | 328 | |
| chr11:3,580,829–3,581,470 | 200.4 kb | Distal (>10kb) Multiome | 80 | |
| chr11:3,614,331–3,614,934 | 233.7 kb | Distal (>10kb) Multiome | 150 | |
| chr11:3,641,420–3,643,023 | 261.3 kb | Distal (>10kb) Multiome | 679 |
Genomic view of the ENSG00000290960 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.