Transcription factors with Perturb-seq knockdown data for ENSG00000290935. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290935 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290935, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:175,871,487–175,872,415 | 283.7 kb | Distal (>10kb) Multiome | 832 | |
| chr5:176,152,219–176,152,545 | 3.0 kb | Proximal (<10kb) | 55 | |
| chr5:176,152,651–176,153,173 | 2.3 kb | Proximal (<10kb) | 38 | |
| chr5:176,172,154–176,172,641 | 17.0 kb | Distal (>10kb) Multiome | 15 | |
| chr5:176,183,360–176,184,067 | 28.3 kb | Distal (>10kb) Multiome | 165 | |
| chr5:176,361,095–176,362,133 | 206.2 kb | Distal (>10kb) Multiome | 877 | |
| chr5:176,365,184–176,366,532 | 210.0 kb | Distal (>10kb) Multiome | 352 | |
| chr5:176,388,019–176,389,614 | 233.5 kb | Distal (>10kb) Multiome | 1052 | |
| chr5:176,415,859–176,416,971 | 261.1 kb | Distal (>10kb) Multiome | 827 | |
| chr5:176,441,967–176,442,454 | 286.7 kb | Distal (>10kb) Multiome | 166 | |
| chr5:176,447,162–176,449,016 | 292.7 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the ENSG00000290935 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.