Transcription factors with Perturb-seq knockdown data for ENSG00000290927. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290927 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290927, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:31,406,131–31,406,947 | 294.1 kb | Distal (>10kb) Multiome | 214 | |
| chr16:31,442,550–31,443,636 | 257.5 kb | Distal (>10kb) Multiome | 838 | |
| chr16:31,457,952–31,460,456 | 242.5 kb | Distal (>10kb) Multiome | 1128 | |
| chr16:31,471,780–31,473,168 | 227.7 kb | Distal (>10kb) Multiome | 425 | |
| chr16:31,476,391–31,478,207 | 222.8 kb | Distal (>10kb) Multiome HiCAR | 750 | |
| chr16:31,487,298–31,488,862 | 212.7 kb | Distal (>10kb) Multiome HiCAR | 323 | |
| chr16:31,507,726–31,508,748 | 192.2 kb | Distal (>10kb) Multiome HiCAR | 992 | |
| chr16:31,529,299–31,530,211 | 170.9 kb | Distal (>10kb) Multiome | 114 | |
| chr16:31,697,025–31,697,195 | 3.4 kb | Proximal (<10kb) | 135 | |
| chr16:31,700,204–31,701,065 | 7 bp | At TSS Multiome | 787 | |
| chr16:31,709,895–31,710,123 | 9.3 kb | Proximal (<10kb) | 8 | |
| chr16:31,712,839–31,714,180 | 12.7 kb | Distal (>10kb) Multiome | 930 | |
| chr16:31,873,239–31,874,541 | 173.2 kb | Distal (>10kb) Multiome | 714 |
Genomic view of the ENSG00000290927 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.