Transcription factors with Perturb-seq knockdown data for ENSG00000290793. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290793 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290793, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:68,195,930–68,196,516 | 9.0 kb | Proximal (<10kb) | 132 | |
| chr17:68,196,956–68,197,666 | 7.8 kb | Proximal (<10kb) | 226 | |
| chr17:68,198,160–68,198,530 | 7.0 kb | Proximal (<10kb) | 78 | |
| chr17:68,198,840–68,199,804 | 5.7 kb | Proximal (<10kb) | 254 | |
| chr17:68,200,632–68,201,332 | 4.2 kb | Proximal (<10kb) | 510 | |
| chr17:68,205,092–68,206,268 | at TSS | At TSS | 867 |
Genomic view of the ENSG00000290793 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.