Transcription factors with Perturb-seq knockdown data for ENSG00000290685. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290685 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290685, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:93,058,154–93,059,241 | 287.8 kb | Distal (>10kb) Multiome | 417 | |
| chr9:93,094,880–93,097,281 | 250.5 kb | Distal (>10kb) Multiome | 813 | |
| chr9:93,133,298–93,134,791 | 212.2 kb | Distal (>10kb) Multiome | 796 | |
| chr9:93,159,802–93,160,270 | 186.3 kb | Distal (>10kb) Multiome | 500 | |
| chr9:93,183,782–93,185,608 | 162.3 kb | Distal (>10kb) Multiome | 401 | |
| chr9:93,346,091–93,346,711 | 123 bp | At TSS Multiome | 137 | |
| chr9:93,364,969–93,366,461 | 19.3 kb | Distal (>10kb) Multiome | 123 | |
| chr9:93,450,848–93,452,597 | 105.2 kb | Distal (>10kb) Multiome | 770 | |
| chr9:93,453,260–93,453,968 | 107.2 kb | Distal (>10kb) Multiome | 535 | |
| chr9:93,566,407–93,567,185 | 220.2 kb | Distal (>10kb) Multiome | 816 |
Genomic view of the ENSG00000290685 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.