Transcription factors with Perturb-seq knockdown data for ENSG00000290476. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290476 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290476, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:40,651,850–40,652,501 | 269.6 kb | Distal (>10kb) Multiome | 187 | |
| chr13:40,663,960–40,667,930 | 255.0 kb | Distal (>10kb) Multiome | 878 | |
| chr13:40,680,324–40,681,411 | 240.9 kb | Distal (>10kb) Multiome | 281 | |
| chr13:40,770,737–40,771,525 | 150.4 kb | Distal (>10kb) Multiome | 1000 | |
| chr13:40,789,168–40,790,225 | 132.1 kb | Distal (>10kb) Multiome | 837 | |
| chr13:40,921,270–40,922,017 | 99 bp | At TSS Multiome | 675 | |
| chr13:41,060,003–41,062,196 | 140.0 kb | Distal (>10kb) Multiome | 1139 | |
| chr13:41,085,849–41,086,392 | 164.4 kb | Distal (>10kb) Multiome | 126 | |
| chr13:41,107,127–41,108,367 | 185.9 kb | Distal (>10kb) Multiome | 291 | |
| chr13:41,132,141–41,133,085 | 211.1 kb | Distal (>10kb) Multiome | 774 | |
| chr13:41,194,020–41,194,940 | 272.8 kb | Distal (>10kb) Multiome | 837 |
Genomic view of the ENSG00000290476 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.