Transcription factors with Perturb-seq knockdown data for ENSG00000290357. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290357 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290357, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:6,800,522–6,801,235 | 291.4 kb | Distal (>10kb) Multiome | 483 | |
| chr8:6,834,068–6,835,901 | 256.7 kb | Distal (>10kb) Multiome | 395 | |
| chr8:6,840,478–6,841,374 | 251.3 kb | Distal (>10kb) Multiome | 350 | |
| chr8:6,863,803–6,864,675 | 228.3 kb | Distal (>10kb) Multiome | 77 | |
| chr8:7,091,768–7,092,761 | 273 bp | At TSS Multiome | 88 |
Genomic view of the ENSG00000290357 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.