Transcription factors with Perturb-seq knockdown data for ENSG00000290241. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290241 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290241, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:128,581,519–128,582,200 | 268.7 kb | Distal (>10kb) Multiome | 16 | |
| chr3:128,607,947–128,608,800 | 242.1 kb | Distal (>10kb) Multiome | 376 | |
| chr3:128,617,357–128,618,496 | 232.8 kb | Distal (>10kb) Multiome | 735 | |
| chr3:128,650,142–128,651,178 | 199.7 kb | Distal (>10kb) Multiome | 772 | |
| chr3:128,653,061–128,654,283 | 196.7 kb | Distal (>10kb) Multiome | 55 | |
| chr3:128,675,353–128,676,166 | 174.6 kb | Distal (>10kb) Multiome | 103 | |
| chr3:128,680,397–128,681,422 | 169.6 kb | Distal (>10kb) Multiome | 1014 | |
| chr3:128,698,248–128,698,988 | 152.0 kb | Distal (>10kb) Multiome HiCAR | 239 | |
| chr3:128,725,886–128,726,915 | 124.4 kb | Distal (>10kb) Multiome | 900 | |
| chr3:128,832,889–128,833,369 | 17.3 kb | Distal (>10kb) Multiome | 38 | |
| chr3:128,845,614–128,846,390 | 4.5 kb | Proximal (<10kb) Multiome | 538 | |
| chr3:128,878,828–128,880,293 | 29.0 kb | Distal (>10kb) Multiome | 1016 | |
| chr3:128,993,367–128,994,455 | 143.5 kb | Distal (>10kb) Multiome | 344 | |
| chr3:129,027,026–129,027,525 | 176.7 kb | Distal (>10kb) Multiome | 589 | |
| chr3:129,120,244–129,122,947 | 271.5 kb | Distal (>10kb) Multiome | 767 |
Genomic view of the ENSG00000290241 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.