Transcription factors with Perturb-seq knockdown data for ENSG00000290021. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000290021 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000290021, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:187,737,384–187,742,012 | 2.9 kb | Proximal (<10kb) | 974 | |
| chr3:187,742,125–187,742,331 | 2.6 kb | Proximal (<10kb) | 300 | |
| chr3:187,743,635–187,744,497 | 408 bp | At TSS | 309 | |
| chr3:187,744,634–187,746,096 | at TSS | At TSS | 917 | |
| chr3:187,746,753–187,746,900 | 1.8 kb | Proximal (<10kb) | 73 | |
| chr3:187,748,044–187,748,506 | 3.1 kb | Proximal (<10kb) | 475 | |
| chr3:187,750,052–187,750,795 | 5.1 kb | Proximal (<10kb) | 613 |
Genomic view of the ENSG00000290021 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.