Transcription factors with Perturb-seq knockdown data for ENSG00000289974. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289974 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289974, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:136,111,604–136,112,087 | 7.4 kb | Proximal (<10kb) | 25 | |
| chr2:136,112,260–136,113,070 | 6.4 kb | Proximal (<10kb) | 99 | |
| chr2:136,115,192–136,115,948 | 3.5 kb | Proximal (<10kb) | 75 | |
| chr2:136,116,129–136,119,923 | at TSS | At TSS | 623 | |
| chr2:136,125,768–136,126,914 | 6.3 kb | Proximal (<10kb) | 196 | |
| chr2:136,127,705–136,128,180 | 8.2 kb | Proximal (<10kb) | 27 |
Genomic view of the ENSG00000289974 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.