Transcription factors with Perturb-seq knockdown data for ENSG00000289527. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289527 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289527, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:51,073,446–51,075,055 | 964.8 kb | Distal (>10kb) Multiome HiCAR | 475 | |
| chr10:51,914,936–51,915,602 | 124.0 kb | Distal (>10kb) Multiome | 160 | |
| chr10:52,033,685–52,034,200 | 5.0 kb | Proximal (<10kb) | 17 | |
| chr10:52,039,217–52,039,988 | 222 bp | At TSS Multiome | 116 | |
| chr10:52,040,596–52,041,008 | 1.4 kb | Proximal (<10kb) | 36 | |
| chr10:52,308,085–52,309,123 | 269.4 kb | Distal (>10kb) Multiome | 588 | |
| chr10:52,312,997–52,315,411 | 275.2 kb | Distal (>10kb) Multiome | 866 |
Genomic view of the ENSG00000289527 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.