Transcription factors with Perturb-seq knockdown data for ENSG00000289508. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289508 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289508, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:169,930,048–169,930,382 | 9.9 kb | Proximal (<10kb) | 4 | |
| chr4:169,934,787–169,935,471 | 4.8 kb | Proximal (<10kb) | 121 | |
| chr4:169,940,549–169,940,842 | 273 bp | At TSS | 46 | |
| chr4:169,944,040–169,944,353 | 3.8 kb | Proximal (<10kb) | 33 |
Genomic view of the ENSG00000289508 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.