Transcription factors with Perturb-seq knockdown data for ENSG00000289437. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289437 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289437, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:95,003,172–95,003,905 | 256.4 kb | Distal (>10kb) Multiome | 875 | |
| chr12:95,072,721–95,073,838 | 186.5 kb | Distal (>10kb) Multiome | 927 | |
| chr12:95,129,410–95,130,455 | 130.0 kb | Distal (>10kb) Multiome | 158 | |
| chr12:95,216,693–95,218,575 | 42.5 kb | Distal (>10kb) Multiome | 1001 | |
| chr12:95,442,539–95,444,040 | 183.5 kb | Distal (>10kb) Multiome | 107 | |
| chr12:95,446,296–95,447,252 | 186.7 kb | Distal (>10kb) Multiome | 289 | |
| chr12:95,473,495–95,474,647 | 213.9 kb | Distal (>10kb) Multiome | 953 | |
| chr12:95,547,928–95,549,389 | 288.6 kb | Distal (>10kb) Multiome | 471 | |
| chr12:95,551,266–95,551,780 | 291.4 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the ENSG00000289437 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.