Transcription factors with Perturb-seq knockdown data for ENSG00000289435. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289435 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289435, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:181,701,594–181,702,555 | 9.2 kb | Proximal (<10kb) | 283 | |
| chr3:181,704,516–181,705,421 | 6.3 kb | Proximal (<10kb) | 135 | |
| chr3:181,707,992–181,708,401 | 3.3 kb | Proximal (<10kb) | 140 | |
| chr3:181,709,626–181,710,028 | 1.7 kb | Proximal (<10kb) | 249 | |
| chr3:181,710,172–181,713,363 | at TSS | At TSS | 617 | |
| chr3:181,715,499–181,716,222 | 3.8 kb | Proximal (<10kb) | 231 | |
| chr3:181,719,364–181,719,952 | 7.6 kb | Proximal (<10kb) | 89 |
Genomic view of the ENSG00000289435 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.