Transcription factors with Perturb-seq knockdown data for ENSG00000289431. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289431 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289431, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:21,511,651–21,512,630 | 9.2 kb | Proximal (<10kb) | 136 | |
| chr20:21,513,279–21,513,573 | 8.2 kb | Proximal (<10kb) | 68 | |
| chr20:21,513,907–21,516,021 | 5.8 kb | Proximal (<10kb) | 331 | |
| chr20:21,517,806–21,518,236 | 3.5 kb | Proximal (<10kb) | 41 | |
| chr20:21,518,360–21,519,896 | 1.9 kb | Proximal (<10kb) | 128 | |
| chr20:21,521,001–21,522,917 | at TSS | At TSS | 278 | |
| chr20:21,522,987–21,523,361 | 1.2 kb | Proximal (<10kb) | 112 |
Genomic view of the ENSG00000289431 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.