Transcription factors with Perturb-seq knockdown data for ENSG00000289421. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289421 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289421, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:46,184,645–46,185,202 | 273.9 kb | Distal (>10kb) Multiome | 334 | |
| chr21:46,228,249–46,230,022 | 229.6 kb | Distal (>10kb) Multiome | 833 | |
| chr21:46,285,753–46,286,753 | 172.2 kb | Distal (>10kb) Multiome | 983 | |
| chr21:46,323,408–46,325,506 | 134.5 kb | Distal (>10kb) Multiome | 952 | |
| chr21:46,457,952–46,459,810 | 267 bp | At TSS Multiome | 880 | |
| chr21:46,634,895–46,636,502 | 177.1 kb | Distal (>10kb) Multiome | 989 |
Genomic view of the ENSG00000289421 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.