Transcription factors with Perturb-seq knockdown data for ENSG00000289405. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289405 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289405, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:133,568,680–133,573,231 | 1262.1 kb | Distal (>10kb) Multiome HiCAR | 1062 | |
| chr8:134,712,242–134,713,803 | 119.1 kb | Distal (>10kb) Multiome | 973 | |
| chr8:134,831,398–134,833,334 | 466 bp | At TSS Multiome | 1010 | |
| chr8:134,939,887–134,940,994 | 108.4 kb | Distal (>10kb) Multiome | 107 | |
| chr8:135,055,405–135,056,398 | 224.0 kb | Distal (>10kb) Multiome | 101 |
Genomic view of the ENSG00000289405 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.