Transcription factors with Perturb-seq knockdown data for ENSG00000289335. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289335 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289335, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:35,248,647–35,249,942 | 4.8 kb | Proximal (<10kb) | 358 | |
| chr7:35,253,386–35,255,107 | at TSS | At TSS | 357 | |
| chr7:35,256,280–35,256,865 | 1.6 kb | Proximal (<10kb) | 76 | |
| chr7:35,257,289–35,258,565 | 2.6 kb | Proximal (<10kb) | 119 | |
| chr7:35,259,307–35,259,512 | 4.6 kb | Proximal (<10kb) | 16 | |
| chr7:35,261,015–35,262,351 | 6.3 kb | Proximal (<10kb) | 217 | |
| chr7:35,263,294–35,263,692 | 8.6 kb | Proximal (<10kb) | 24 |
Genomic view of the ENSG00000289335 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.