Transcription factors with Perturb-seq knockdown data for ENSG00000289308. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289308 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289308, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:61,516,921–61,517,698 | 252.3 kb | Distal (>10kb) Multiome | 292 | |
| chr4:61,764,329–61,764,731 | 4.9 kb | Proximal (<10kb) | 29 | |
| chr4:61,769,460–61,770,780 | at TSS | At TSS | 143 | |
| chr4:61,773,728–61,774,140 | 4.1 kb | Proximal (<10kb) | 39 | |
| chr4:61,911,058–61,911,810 | 141.9 kb | Distal (>10kb) Multiome HiCAR | 187 |
Genomic view of the ENSG00000289308 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.