Transcription factors with Perturb-seq knockdown data for ENSG00000289224. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289224 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289224, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:45,970,520–45,971,289 | 6.4 kb | Proximal (<10kb) | 325 | |
| chr21:45,972,497–45,973,054 | 4.7 kb | Proximal (<10kb) | 201 | |
| chr21:45,973,174–45,975,630 | 2.1 kb | Proximal (<10kb) | 597 | |
| chr21:45,975,731–45,976,305 | 1.4 kb | Proximal (<10kb) | 48 | |
| chr21:45,977,133–45,977,741 | at TSS | At TSS | 72 | |
| chr21:45,981,076–45,982,605 | 3.4 kb | Proximal (<10kb) | 580 |
Genomic view of the ENSG00000289224 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.