Transcription factors with Perturb-seq knockdown data for ENSG00000289201. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289201 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289201, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:24,469,795–24,472,485 | 2.6 kb | Proximal (<10kb) Multiome | 494 | |
| chr4:24,472,584–24,473,681 | 136 bp | At TSS Multiome | 565 | |
| chr4:24,583,502–24,585,060 | 111.6 kb | Distal (>10kb) Multiome | 872 | |
| chr4:24,661,948–24,662,562 | 189.3 kb | Distal (>10kb) Multiome | 55 |
Genomic view of the ENSG00000289201 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.