Transcription factors with Perturb-seq knockdown data for ENSG00000289121. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289121 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289121, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:160,981,323–160,982,552 | 64.3 kb | Distal (>10kb) Multiome | 156 | |
| chr1:161,020,536–161,021,920 | 24.8 kb | Distal (>10kb) Multiome | 846 | |
| chr1:161,037,710–161,037,969 | 8.1 kb | Proximal (<10kb) | 44 | |
| chr1:161,038,489–161,039,130 | 7.2 kb | Proximal (<10kb) Multiome | 468 | |
| chr1:161,041,560–161,041,780 | 4.2 kb | Proximal (<10kb) | 84 | |
| chr1:161,045,080–161,046,516 | 81 bp | At TSS Multiome | 927 | |
| chr1:161,097,691–161,099,047 | 52.3 kb | Distal (>10kb) Multiome HiCAR | 829 | |
| chr1:161,117,504–161,118,419 | 72.0 kb | Distal (>10kb) Multiome | 794 | |
| chr1:161,131,760–161,133,351 | 86.6 kb | Distal (>10kb) Multiome | 956 | |
| chr1:161,153,700–161,154,461 | 108.0 kb | Distal (>10kb) Multiome | 816 | |
| chr1:161,158,928–161,160,167 | 113.5 kb | Distal (>10kb) Multiome | 706 | |
| chr1:161,165,740–161,167,170 | 120.3 kb | Distal (>10kb) Multiome | 888 | |
| chr1:161,176,874–161,177,972 | 131.5 kb | Distal (>10kb) Multiome | 910 | |
| chr1:161,198,215–161,199,209 | 152.5 kb | Distal (>10kb) Multiome | 357 | |
| chr1:161,201,572–161,202,783 | 156.3 kb | Distal (>10kb) Multiome | 852 | |
| chr1:161,225,326–161,226,910 | 179.9 kb | Distal (>10kb) Multiome | 710 | |
| chr1:161,227,235–161,227,802 | 181.5 kb | Distal (>10kb) Multiome | 372 | |
| chr1:161,258,515–161,259,098 | 212.7 kb | Distal (>10kb) Multiome | 281 | |
| chr1:161,305,737–161,306,708 | 260.3 kb | Distal (>10kb) Multiome | 430 | |
| chr1:161,313,977–161,314,703 | 268.3 kb | Distal (>10kb) Multiome | 824 |
Genomic view of the ENSG00000289121 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.