Transcription factors with Perturb-seq knockdown data for ENSG00000289047. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000289047 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000289047, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:32,837,981–32,838,977 | 55.6 kb | Distal (>10kb) Multiome | 821 | |
| chr6:32,844,222–32,845,071 | 49.6 kb | Distal (>10kb) Multiome | 534 | |
| chr6:32,853,077–32,854,448 | 40.3 kb | Distal (>10kb) Multiome | 841 | |
| chr6:32,893,822–32,895,230 | 299 bp | At TSS Multiome | 774 | |
| chr6:32,952,883–32,953,496 | 58.9 kb | Distal (>10kb) Multiome | 366 | |
| chr6:32,967,972–32,971,214 | 74.5 kb | Distal (>10kb) Multiome | 1227 | |
| chr6:32,971,467–32,973,408 | 77.7 kb | Distal (>10kb) Multiome | 1115 | |
| chr6:33,009,348–33,009,899 | 115.4 kb | Distal (>10kb) Multiome | 184 | |
| chr6:33,161,505–33,162,100 | 267.4 kb | Distal (>10kb) Multiome | 589 |
Genomic view of the ENSG00000289047 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.