TFs regulating ENSG00000288880 0 TFs

Transcription factors with Perturb-seq knockdown data for ENSG00000288880. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288880 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENSG00000288880

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288880, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:150,363,368–150,364,980	265.8 kb	Distal (>10kb) Multiome	971
chr1:150,487,154–150,487,710	142.5 kb	Distal (>10kb) Multiome	929
chr1:150,515,085–150,516,227	114.1 kb	Distal (>10kb) Multiome	781
chr1:150,548,849–150,549,823	80.6 kb	Distal (>10kb) Multiome	620
chr1:150,560,828–150,562,623	68.5 kb	Distal (>10kb) Multiome	897
chr1:150,578,554–150,580,300	50.2 kb	Distal (>10kb) Multiome	990
chr1:150,627,434–150,628,113	1.7 kb	Proximal (<10kb)	52
chr1:150,629,012–150,630,122	323 bp	At TSS Multiome	875
chr1:150,634,804–150,635,486	5.4 kb	Proximal (<10kb) Multiome	113
chr1:150,641,008–150,641,820	11.8 kb	Distal (>10kb) Multiome	66
chr1:150,696,984–150,697,716	67.5 kb	Distal (>10kb) Multiome	619
chr1:150,875,863–150,877,222	246.9 kb	Distal (>10kb) Multiome	912
chr1:150,925,543–150,926,754	296.5 kb	Distal (>10kb) Multiome	813

Genome Browser

Genomic view of the ENSG00000288880 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.