Transcription factors with Perturb-seq knockdown data for ENSG00000288075. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000288075 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000288075, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:8,857,204–8,857,659 | 294.6 kb | Distal (>10kb) Multiome | 73 | |
| chr4:8,859,498–8,862,107 | 291.3 kb | Distal (>10kb) Multiome | 274 | |
| chr4:8,867,617–8,868,531 | 284.3 kb | Distal (>10kb) Multiome | 58 | |
| chr4:8,871,141–8,873,019 | 280.2 kb | Distal (>10kb) Multiome | 297 | |
| chr4:8,893,059–8,894,465 | 258.3 kb | Distal (>10kb) Multiome | 143 | |
| chr4:8,964,099–8,964,874 | 187.8 kb | Distal (>10kb) Multiome | 64 | |
| chr4:9,000,532–9,001,331 | 151.5 kb | Distal (>10kb) Multiome | 130 | |
| chr4:9,068,261–9,068,740 | 83.7 kb | Distal (>10kb) Multiome | 30 | |
| chr4:9,151,827–9,154,021 | 527 bp | At TSS Multiome | 453 | |
| chr4:9,380,958–9,381,519 | at TSS | At TSS | 42 |
Genomic view of the ENSG00000288075 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.