Transcription factors with Perturb-seq knockdown data for ENSG00000287917. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287917 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287917, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,027,243–65,027,944 | 287.2 kb | Distal (>10kb) Multiome | 851 | |
| chr11:65,040,595–65,041,884 | 273.6 kb | Distal (>10kb) Multiome | 838 | |
| chr11:65,083,636–65,084,788 | 230.5 kb | Distal (>10kb) Multiome | 898 | |
| chr11:65,095,834–65,097,052 | 218.2 kb | Distal (>10kb) Multiome | 1061 | |
| chr11:65,111,466–65,113,404 | 202.9 kb | Distal (>10kb) Multiome | 919 | |
| chr11:65,116,528–65,118,298 | 196.9 kb | Distal (>10kb) Multiome | 973 | |
| chr11:65,121,474–65,122,848 | 192.5 kb | Distal (>10kb) Multiome | 817 | |
| chr11:65,134,120–65,135,530 | 179.7 kb | Distal (>10kb) Multiome | 997 | |
| chr11:65,180,773–65,182,676 | 133.3 kb | Distal (>10kb) Multiome | 832 | |
| chr11:65,184,109–65,184,542 | 130.4 kb | Distal (>10kb) Multiome | 85 | |
| chr11:65,213,383–65,213,853 | 101.1 kb | Distal (>10kb) Multiome | 174 | |
| chr11:65,225,439–65,226,037 | 89.1 kb | Distal (>10kb) Multiome | 522 | |
| chr11:65,261,186–65,262,526 | 52.9 kb | Distal (>10kb) Multiome | 777 | |
| chr11:65,314,302–65,316,053 | 42 bp | At TSS Multiome | 803 | |
| chr11:65,333,360–65,334,372 | 19.2 kb | Distal (>10kb) Multiome | 654 | |
| chr11:65,354,023–65,355,987 | 39.9 kb | Distal (>10kb) Multiome | 677 | |
| chr11:65,386,320–65,387,097 | 71.9 kb | Distal (>10kb) Multiome | 757 | |
| chr11:65,416,383–65,417,015 | 101.8 kb | Distal (>10kb) Multiome | 664 | |
| chr11:65,417,855–65,419,687 | 104.4 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:65,421,858–65,423,533 | 107.7 kb | Distal (>10kb) Multiome | 1197 | |
| chr11:65,454,735–65,455,360 | 140.4 kb | Distal (>10kb) Multiome | 573 | |
| chr11:65,477,100–65,477,990 | 162.9 kb | Distal (>10kb) Multiome | 991 | |
| chr11:65,487,451–65,488,490 | 173.0 kb | Distal (>10kb) Multiome | 706 | |
| chr11:65,496,515–65,498,726 | 182.9 kb | Distal (>10kb) Multiome | 1059 | |
| chr11:65,524,475–65,525,724 | 210.3 kb | Distal (>10kb) Multiome | 711 | |
| chr11:65,538,923–65,541,339 | 225.0 kb | Distal (>10kb) Multiome | 733 | |
| chr11:65,546,285–65,547,091 | 232.0 kb | Distal (>10kb) Multiome | 529 | |
| chr11:65,553,318–65,554,003 | 238.9 kb | Distal (>10kb) Multiome | 195 | |
| chr11:65,569,718–65,570,745 | 255.6 kb | Distal (>10kb) Multiome | 930 | |
| chr11:65,571,973–65,573,008 | 257.8 kb | Distal (>10kb) Multiome | 420 | |
| chr11:65,573,788–65,575,269 | 259.6 kb | Distal (>10kb) Multiome | 742 | |
| chr11:65,591,808–65,592,698 | 277.5 kb | Distal (>10kb) Multiome | 169 | |
| chr11:65,606,536–65,607,917 | 292.5 kb | Distal (>10kb) Multiome | 376 | |
| chr11:65,613,478–65,614,645 | 299.5 kb | Distal (>10kb) Multiome | 702 |
Genomic view of the ENSG00000287917 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.