Transcription factors with Perturb-seq knockdown data for ENSG00000287862. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287862 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287862, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:88,052,026–88,052,922 | at TSS | At TSS | 130 | |
| chr5:88,140,327–88,142,256 | 88.9 kb | Distal (>10kb) Multiome | 616 | |
| chr5:88,268,309–88,269,790 | 216.3 kb | Distal (>10kb) Multiome | 803 | |
| chr5:88,680,113–88,681,161 | 628.0 kb | Distal (>10kb) Multiome HiCAR | 559 | |
| chr5:88,684,266–88,685,701 | 632.4 kb | Distal (>10kb) Multiome HiCAR | 236 |
Genomic view of the ENSG00000287862 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.