Transcription factors with Perturb-seq knockdown data for ENSG00000287720. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287720 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287720, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:3,179,188–3,180,181 | 862.9 kb | Distal (>10kb) Multiome HiCAR | 973 | |
| chr3:3,798,384–3,800,548 | 243.3 kb | Distal (>10kb) Multiome | 425 | |
| chr3:4,071,181–4,072,083 | 29.1 kb | Distal (>10kb) Multiome | 153 | |
| chr3:4,302,729–4,304,211 | 260.9 kb | Distal (>10kb) Multiome | 854 |
Genomic view of the ENSG00000287720 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.