Transcription factors with Perturb-seq knockdown data for ENSG00000287252. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287252 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287252, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:27,752,061–27,752,956 | 4.5 kb | Proximal (<10kb) | 499 | |
| chr6:27,753,073–27,753,588 | 3.9 kb | Proximal (<10kb) | 758 | |
| chr6:27,754,078–27,754,375 | 3.1 kb | Proximal (<10kb) | 425 | |
| chr6:27,757,291–27,757,718 | at TSS | At TSS | 192 | |
| chr6:27,762,370–27,762,921 | 4.9 kb | Proximal (<10kb) | 65 |
Genomic view of the ENSG00000287252 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.