Transcription factors with Perturb-seq knockdown data for ENSG00000287100. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287100 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287100, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:119,077,736–119,079,370 | 271.1 kb | Distal (>10kb) Multiome | 903 | |
| chr6:119,326,302–119,327,278 | 23.1 kb | Distal (>10kb) Multiome | 173 | |
| chr6:119,340,412–119,342,097 | 8.6 kb | Proximal (<10kb) Multiome | 314 | |
| chr6:119,347,500–119,347,680 | 2.2 kb | Proximal (<10kb) | 409 | |
| chr6:119,347,969–119,350,913 | 43 bp | At TSS Multiome | 1086 | |
| chr6:119,830,134–119,831,420 | 480.7 kb | Distal (>10kb) Multiome HiCAR | 124 | |
| chr6:120,930,265–120,932,413 | 1581.9 kb | Distal (>10kb) Multiome HiCAR | 257 |
Genomic view of the ENSG00000287100 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.