Transcription factors with Perturb-seq knockdown data for ENSG00000287040. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000287040 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000287040, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:159,891,601–159,891,875 | 8.6 kb | Proximal (<10kb) | 325 | |
| chr1:159,891,987–159,893,486 | 7.0 kb | Proximal (<10kb) | 53 | |
| chr1:159,899,910–159,900,706 | at TSS | At TSS | 349 | |
| chr1:159,900,829–159,901,475 | 355 bp | At TSS | 103 | |
| chr1:159,909,082–159,909,741 | 8.6 kb | Proximal (<10kb) | 114 | |
| chr1:159,909,983–159,911,830 | 9.5 kb | Proximal (<10kb) | 438 |
Genomic view of the ENSG00000287040 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.