Transcription factors with Perturb-seq knockdown data for ENSG00000286468. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286468 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286468, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:146,809,617–146,810,362 | 283.3 kb | Distal (>10kb) Multiome | 20 | |
| chr5:146,877,802–146,879,317 | 214.5 kb | Distal (>10kb) Multiome | 376 | |
| chr5:147,040,856–147,042,434 | 51.2 kb | Distal (>10kb) Multiome | 102 | |
| chr5:147,098,070–147,098,807 | 4.8 kb | Proximal (<10kb) | 218 | |
| chr5:147,234,227–147,235,490 | 141.7 kb | Distal (>10kb) Multiome | 281 | |
| chr5:147,384,143–147,385,012 | 291.3 kb | Distal (>10kb) Multiome | 122 |
Genomic view of the ENSG00000286468 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.