Transcription factors with Perturb-seq knockdown data for ENSG00000286369. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286369 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286369, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:67,990,829–67,991,405 | 281.0 kb | Distal (>10kb) Multiome | 54 | |
| chr11:67,996,583–67,997,678 | 275.1 kb | Distal (>10kb) Multiome | 394 | |
| chr11:68,002,991–68,004,268 | 268.0 kb | Distal (>10kb) Multiome | 634 | |
| chr11:68,030,139–68,031,153 | 241.5 kb | Distal (>10kb) Multiome | 708 | |
| chr11:68,038,378–68,039,498 | 233.2 kb | Distal (>10kb) Multiome | 819 | |
| chr11:68,120,465–68,122,314 | 150.6 kb | Distal (>10kb) Multiome | 921 | |
| chr11:68,127,759–68,129,017 | 143.6 kb | Distal (>10kb) Multiome | 604 | |
| chr11:68,212,619–68,214,642 | 59.2 kb | Distal (>10kb) Multiome | 967 | |
| chr11:68,271,213–68,272,543 | 59 bp | At TSS Multiome | 943 | |
| chr11:68,312,404–68,312,863 | 40.6 kb | Distal (>10kb) Multiome | 279 | |
| chr11:68,459,835–68,461,497 | 188.4 kb | Distal (>10kb) Multiome | 1017 |
Genomic view of the ENSG00000286369 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.