Transcription factors with Perturb-seq knockdown data for ENSG00000286362. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286362 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286362, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:119,638,540–119,639,410 | 193.9 kb | Distal (>10kb) Multiome | 275 | |
| chr8:119,672,030–119,673,835 | 159.6 kb | Distal (>10kb) Multiome | 397 | |
| chr8:119,832,338–119,833,429 | 14 bp | At TSS Multiome | 811 | |
| chr8:119,855,284–119,857,254 | 23.0 kb | Distal (>10kb) Multiome | 941 | |
| chr8:119,873,210–119,874,965 | 40.8 kb | Distal (>10kb) Multiome | 871 | |
| chr8:120,047,941–120,048,921 | 215.4 kb | Distal (>10kb) Multiome | 198 | |
| chr8:120,123,318–120,126,661 | 290.8 kb | Distal (>10kb) Multiome | 769 |
Genomic view of the ENSG00000286362 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.