Transcription factors with Perturb-seq knockdown data for ENSG00000286191. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286191 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286191, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:50,377,025–50,377,266 | 9.9 kb | Proximal (<10kb) | 47 | |
| chr13:50,386,911–50,387,023 | 134 bp | At TSS | 86 | |
| chr13:50,387,130–50,387,304 | at TSS | At TSS | 158 | |
| chr13:50,389,982–50,390,480 | 2.8 kb | Proximal (<10kb) | 37 | |
| chr13:50,390,591–50,391,130 | 3.4 kb | Proximal (<10kb) | 54 |
Genomic view of the ENSG00000286191 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.