Transcription factors with Perturb-seq knockdown data for ENSG00000286046. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000286046 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000286046, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:17,576,452–17,578,383 | 841.4 kb | Distal (>10kb) Multiome HiCAR | 874 | |
| chr4:18,417,830–18,419,146 | 179 bp | At TSS Multiome | 203 | |
| chr4:18,691,088–18,692,442 | 272.9 kb | Distal (>10kb) Multiome | 397 |
Genomic view of the ENSG00000286046 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.