Transcription factors with Perturb-seq knockdown data for ENSG00000285759. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285759 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285759, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:10,416,662–10,418,068 | 8.6 kb | Proximal (<10kb) | 274 | |
| chr6:10,418,929–10,420,110 | 6.5 kb | Proximal (<10kb) | 403 | |
| chr6:10,420,583–10,420,904 | 5.7 kb | Proximal (<10kb) | 41 | |
| chr6:10,421,125–10,422,059 | 4.6 kb | Proximal (<10kb) | 119 | |
| chr6:10,423,158–10,424,767 | 1.9 kb | Proximal (<10kb) | 342 | |
| chr6:10,425,580–10,427,086 | at TSS | At TSS | 534 | |
| chr6:10,429,555–10,430,118 | 2.9 kb | Proximal (<10kb) | 249 | |
| chr6:10,435,196–10,435,372 | 8.6 kb | Proximal (<10kb) | 94 |
Genomic view of the ENSG00000285759 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.