Transcription factors with Perturb-seq knockdown data for ENSG00000285583. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000285583 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000285583, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:12,664,457–12,664,721 | 6.3 kb | Proximal (<10kb) | 64 | |
| chr19:12,666,317–12,667,225 | 3.8 kb | Proximal (<10kb) | 495 | |
| chr19:12,669,351–12,669,939 | 1.1 kb | Proximal (<10kb) | 777 | |
| chr19:12,672,121–12,672,300 | 1.1 kb | Proximal (<10kb) | 206 | |
| chr19:12,676,416–12,676,669 | 5.4 kb | Proximal (<10kb) | 276 | |
| chr19:12,681,003–12,682,117 | 10.0 kb | Proximal (<10kb) | 994 |
Genomic view of the ENSG00000285583 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.