Transcription factors with Perturb-seq knockdown data for ENSG00000284968. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000284968 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000284968, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:86,891,788–86,892,917 | 44.0 kb | Distal (>10kb) Multiome | 698 | |
| chr4:86,934,199–86,936,649 | 1.2 kb | Proximal (<10kb) Multiome | 1055 | |
| chr4:86,940,125–86,940,499 | 3.9 kb | Proximal (<10kb) | 77 | |
| chr4:86,959,519–86,960,442 | 23.8 kb | Distal (>10kb) Multiome | 307 | |
| chr4:87,001,210–87,001,937 | 65.4 kb | Distal (>10kb) Multiome HiCAR | 141 | |
| chr4:87,006,030–87,007,611 | 70.8 kb | Distal (>10kb) Multiome HiCAR | 1004 | |
| chr4:87,030,741–87,031,834 | 95.1 kb | Distal (>10kb) Multiome HiCAR | 395 | |
| chr4:87,219,648–87,221,398 | 284.4 kb | Distal (>10kb) Multiome | 820 |
Genomic view of the ENSG00000284968 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.